Values of the systemic immunity in patients suffering from acne with different clinical course.

ABSTRACT

OBJECTIVE: Introduction: Acne is chronic recurrent dermatosis, one of the essential skin inflammation in the structure of dermatological pathology, especially in young people of working age, often caused by persistent cicatricial changes in the skin, and affecting negatively the psychoemotional state of patients, their quality of life and working capacity. It has been established by today that the pathogenesis acne is complex and multifactorial, and the changes of immune reactivity of the organism play an important role in its clinical course development. The aim of the article is to determine and analyze the values of the systemic immunity in patients suffering from acne with different clinical course. PATIENTS AND METHODS: Materials and methods: 128 patients with acne aged from 18 to 35, among which 74 women (57,8 %) and 54 men (42,2 %) were observed. According to the clinical criteria, 26 patients (20,31%) were diagnosed with comedonal form of acne, 40 patients (31.25%) had papules, 10 people (7.81%) -papular-pustular acne, 29 of the observed (22.65%) had pustules, 9 patients (7.03%) suffered from acne conglobata, and 14 patients (10.94%) were diagnosed with post-acne. The control group consisted of 34 practically healthy people (donors) of the same age. RESULTS: Results: Consequently, most of the patients with acne had varying degrees of changes in rates of systemic immunity - the likely reduction in relative and absolute number of total lymphocytes, T-lymphocytes and their subpopulations against the growing number of B lymphocytes and the level of IgM and IgG, which generally indicates the formation in these patients secondary immunodeficiency state of T-link intensified by activation of humoral immunity in response to the development of skin inflammation. The most significant changes in rates of systemic immunity with the depletion of T-cell immunity were found in patients with papular-pustular and pustular acne, and still more significant - in patients with acne conglobate, which justifies differentiated treatment by immunomotropic drugs for these patients. CONCLUSION: Conclusion: In patients with acne, changes in systemic immunity indexes that indicate the formation of secondary immunodeficiency state T-cell link, amid an adequate humoral immunity have been found. Relationship between the causes of changes of systemic immunity has been established.