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Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors.
Veenstra, Siem Jakob; Rueeger, Heinrich; Voegtle, Markus; Lueoend, Rainer; Holzer, Philipp; Hurth, Konstanze; Tintelnot-Blomley, Marina; Frederiksen, Mathias; Rondeau, Jean-Michel; Jacobson, Laura; Staufenbiel, Matthias; Neumann, Ulf; Machauer, Rainer.
Affiliation
  • Veenstra SJ; Department of Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4057 Basel, Switzerland.
  • Rueeger H; Department of Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4057 Basel, Switzerland.
  • Voegtle M; Department of Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4057 Basel, Switzerland.
  • Lueoend R; Department of Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4057 Basel, Switzerland.
  • Holzer P; Department of Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4057 Basel, Switzerland.
  • Hurth K; Department of Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4057 Basel, Switzerland.
  • Tintelnot-Blomley M; Department of Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4057 Basel, Switzerland.
  • Frederiksen M; Department of Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4057 Basel, Switzerland.
  • Rondeau JM; Center for Proteomic Chemistry, Structural Biology Platform, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4057 Basel, Switzerland.
  • Jacobson L; Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4057 Basel, Switzerland.
  • Staufenbiel M; Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4057 Basel, Switzerland.
  • Neumann U; Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4057 Basel, Switzerland.
  • Machauer R; Department of Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4057 Basel, Switzerland. Electronic address: rainer.machauer@novartis.com.
Bioorg Med Chem Lett ; 28(12): 2195-2200, 2018 07 01.
Article in En | MEDLINE | ID: mdl-29764741
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxazines / Aspartic Acid Endopeptidases / Enzyme Inhibitors / Amyloid Precursor Protein Secretases / Drug Discovery Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Type: Article Affiliation country: Switzerland
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxazines / Aspartic Acid Endopeptidases / Enzyme Inhibitors / Amyloid Precursor Protein Secretases / Drug Discovery Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Type: Article Affiliation country: Switzerland