<sup>86/90</sup>Y-Based Theranostics Targeting Angiogenesis in a Murine Breast Cancer Model.

Ehlerding, Emily B; Ferreira, Carolina A; Aluicio-Sarduy, Eduardo; Jiang, Dawei; Lee, Hye Jin; Theuer, Charles P; Engle, Jonathan W; Cai, Weibo

^86/90Y-Based Theranostics Targeting Angiogenesis in a Murine Breast Cancer Model.

Ehlerding, Emily B; Ferreira, Carolina A; Aluicio-Sarduy, Eduardo; Jiang, Dawei; Lee, Hye Jin; Theuer, Charles P; Engle, Jonathan W; Cai, Weibo.

Affiliation

Ferreira CA; Department of Biomedical Engineering , Univesity of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.
Theuer CP; TRACON Pharmaceuticals, Inc. , San Diego , California 92122 , United States.
Cai W; Department of Biomedical Engineering , Univesity of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.

Mol Pharm ; 15(7): 2606-2613, 2018 07 02.

Article in En | MEDLINE | ID: mdl-29787283

Subject(s)

Antineoplastic Agents/pharmacology; Immunoconjugates/pharmacology; Mammary Neoplasms, Experimental/radiotherapy; Neovascularization, Pathologic/drug therapy; Radioimmunotherapy/methods; Theranostic Nanomedicine/methods; Animals; Antibodies, Monoclonal/chemistry; Antibodies, Monoclonal/pharmacology; Antibodies, Monoclonal/therapeutic use; Antineoplastic Agents/chemistry; Antineoplastic Agents/therapeutic use; Cell Line, Tumor/transplantation; Drug Screening Assays, Antitumor; Female; Humans; Immunoconjugates/chemistry; Immunoconjugates/therapeutic use; Mammary Neoplasms, Experimental/diagnostic imaging; Mammary Neoplasms, Experimental/pathology; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic/diagnostic imaging; Positron-Emission Tomography/methods; Tissue Distribution; Treatment Outcome; Yttrium Radioisotopes/chemistry; Yttrium Radioisotopes/pharmacology; Yttrium Radioisotopes/therapeutic use

Key words

CD105/endoglin; angiogenesis; cancer; positron emission tomography (PET); radioimmunotherapy; theranostics; yttrium-86; yttrium-90

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radioimmunotherapy / Immunoconjugates / Theranostic Nanomedicine / Mammary Neoplasms, Experimental / Neovascularization, Pathologic / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2018 Type: Article

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