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Histological and Molecular Adipose Tissue Changes Are Related to Metabolic Syndrome Rather Than Lipodystrophy in Human Immunodeficiency Virus-Infected Patients: A Cross-Sectional Study.
Langkilde, Anne; Tavenier, Juliette; Danielsen, Allan Vestergaard; Eugen-Olsen, Jesper; Therkildsen, Christina; Jensen, Frank Krieger; Henriksen, Jens Henrik; Langberg, Henning; Steiniche, Torben; Petersen, Janne; Holck, Susanne; Andersen, Ove.
Affiliation
  • Langkilde A; Optimed, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.
  • Tavenier J; Optimed, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.
  • Danielsen AV; Institute of Pathology, Aarhus University Hospital, Denmark.
  • Eugen-Olsen J; Optimed, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.
  • Therkildsen C; Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.
  • Jensen FK; Department of Radiology, Copenhagen University Hospital, Hvidovre, Denmark.
  • Henriksen JH; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Hvidovre, Denmark.
  • Langberg H; CopenRehab, Department of Public Health, Section of Social Medicine, University of Copenhagen, Denmark.
  • Steiniche T; Institute of Pathology, Aarhus University Hospital, Denmark.
  • Petersen J; Optimed, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.
  • Holck S; Department of Biostatistics, University of Copenhagen, Denmark.
  • Andersen O; Department of Pathology, Copenhagen University Hospital, Hvidovre, Denmark.
J Infect Dis ; 218(7): 1090-1098, 2018 08 24.
Article in En | MEDLINE | ID: mdl-29788076
Background: In human immunodeficiency virus (HIV)-infected patients on combination antiretroviral therapy (cART), lipodystrophy shares many similarities with metabolic syndrome, but only metabolic syndrome has objective classification criteria. We examined adipose tissue changes related to lipodystrophy and metabolic syndrome to clarify whether it may be acceptable to focus diagnosis on metabolic syndrome rather than lipodystrophy. Methods: This is a cross-sectional study of 60 HIV-infected men on cART and 15 healthy men. We evaluated lipodystrophy (clinical assessment) and metabolic syndrome (JIS-2009). We compared adipocyte size, leukocyte infiltration, and gene expression in abdominal subcutaneous adipose tissue biopsies of patients with and without lipodystrophy and with and without metabolic syndrome. Results: Lipodystrophy was only associated with increased macrophage infiltration (P = .04) and adiponectin messenger ribonucleic acid ([mRNA] P = .008), whereas metabolic syndrome was associated with larger adipocytes (P < .0001), decreased expression of genes related to adipogenesis and adipocyte function (P values between <.0001 and .08), increased leptin mRNA (P = .04), and a trend towards increased expression of inflammatory genes (P values between .08 and .6). Conclusions: Metabolic syndrome rather than lipodystrophy was associated with major unfavorable abdominal subcutaneous adipose tissue changes. In a clinical setting, it may be more relevant to focus on metabolic syndrome diagnosis in HIV-infected patients on cART with regards to adipose tissue dysfunction and risk of cardiometabolic complications.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / HIV / Metabolic Syndrome / Anti-Retroviral Agents Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Humans / Male / Middle aged Language: En Journal: J Infect Dis Year: 2018 Type: Article Affiliation country: Denmark

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / HIV / Metabolic Syndrome / Anti-Retroviral Agents Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Humans / Male / Middle aged Language: En Journal: J Infect Dis Year: 2018 Type: Article Affiliation country: Denmark