Synthesis of novel hetero ring fused pyridine derivatives; Their anticancer activity, CoMFA and CoMSIA studies.

Santhosh Kumar, G; Poornachandra, Y; Kumar Gunda, Shravan; Ratnakar Reddy, K; Mohmed, Jaheer; Shaik, Kamal; Ganesh Kumar, C; Narsaiah, B

Santhosh Kumar, G; Poornachandra, Y; Kumar Gunda, Shravan; Ratnakar Reddy, K; Mohmed, Jaheer; Shaik, Kamal; Ganesh Kumar, C; Narsaiah, B.

Affiliation

Santhosh Kumar G; Fluoro Organic Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
Poornachandra Y; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
Kumar Gunda S; Bioinformatics Division, PGRRCDE, Osmania University, Hyderabad 500007, India.
Ratnakar Reddy K; Fluoro Organic Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
Mohmed J; Bioinformatics Division, PGRRCDE, Osmania University, Hyderabad 500007, India.
Shaik K; Department of Chemical Engineering, Visvesvaraya National Institute of Technology, Nagpur 440010, India.
Ganesh Kumar C; Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
Narsaiah B; Fluoro Organic Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India. Electronic address: narsaiah@iict.res.in.

Bioorg Med Chem Lett ; 28(13): 2328-2337, 2018 07 15.

Article in En | MEDLINE | ID: mdl-29798826

Subject(s)

Antineoplastic Agents/pharmacology; Heterocyclic Compounds, 2-Ring/pharmacology; Heterocyclic Compounds, 3-Ring/pharmacology; Pyridines/pharmacology; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/chemistry; Antineoplastic Agents/toxicity; Cell Line, Tumor; Cyclization; Drug Screening Assays, Antitumor; Furans/chemical synthesis; Furans/chemistry; Furans/pharmacology; Furans/toxicity; HEK293 Cells; Heterocyclic Compounds, 2-Ring/chemical synthesis; Heterocyclic Compounds, 2-Ring/chemistry; Heterocyclic Compounds, 2-Ring/toxicity; Heterocyclic Compounds, 3-Ring/chemical synthesis; Heterocyclic Compounds, 3-Ring/chemistry; Heterocyclic Compounds, 3-Ring/toxicity; Humans; Hydrogen Bonding; Molecular Structure; Pyridines/chemical synthesis; Pyridines/chemistry; Pyridines/toxicity; Pyrimidines/chemical synthesis; Pyrimidines/chemistry; Pyrimidines/pharmacology; Pyrimidines/toxicity; Quantitative Structure-Activity Relationship

Key words

3D QSAR; Anti-cancer activity; Carbohydrazide Schiff's bases; CoMFA and CoMSIA studies; Pyrido[3',2':4,5]furo[3,2-d]pyrimidin-4(3H)-one

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Heterocyclic Compounds, 2-Ring / Heterocyclic Compounds, 3-Ring / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Type: Article Affiliation country: India

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