The Choroid Plexus Functions as a Niche for T-Cell Stimulation Within the Central Nervous System.
Front Immunol
; 9: 1066, 2018.
Article
in En
| MEDLINE
| ID: mdl-29868025
ABSTRACT
The choroid plexus (CP) compartment in the ventricles of the brain comprises fenestrated vasculature and, therefore, it is permeable to blood-borne mediators of inflammation. Here, we explored whether T-cell activation in the CP plays a role in regulating central nervous system (CNS) inflammation. We show that CD4 T cells injected into the lateral ventricles adhere to the CP, transmigrate across its epithelium, and undergo antigen-specific activation and proliferation. This process is enhanced following peripheral immune stimulation and significantly impacts the immune signaling induced by the CP. Ex vivo studies demonstrate that T-cell harboring the CP through its apical surface is a chemokine- and adhesion molecule-dependent process. We suggest that, within the CNS, the CP serves an immunological niche, which rapidly responds to peripheral inflammation and, thereby, promotes two-way T-cell trafficking that impact adaptive immunity in the CNS.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
T-Lymphocytes
/
Central Nervous System
/
Choroid Plexus
/
Cellular Microenvironment
Limits:
Animals
Language:
En
Journal:
Front Immunol
Year:
2018
Type:
Article
Affiliation country:
Israel