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A haunted beast: Targeting STAT5BN642H in T-Cell Neoplasia.
Pham, Ha Thi Thanh; Hengstschläger, Markus; Moriggl, Richard.
Affiliation
  • Pham HTT; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
  • Hengstschläger M; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.
  • Moriggl R; Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria.
Mol Cell Oncol ; 5(3): e1435181, 2018.
Article in En | MEDLINE | ID: mdl-29876519
ABSTRACT
The somatic hot spot mutation STAT5BN642H was found in many T cell leukemia/lymphoma patients. We generated and analyzed a transgenic mouse model with hematopoietic STAT5BN642H expression that caused aggressive T-cell leukemia/lymphomas. Herein, we discuss the scientific merit of our model and its relevance for pre-clinical studies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Mol Cell Oncol Year: 2018 Type: Article Affiliation country: Austria
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Mol Cell Oncol Year: 2018 Type: Article Affiliation country: Austria