Valproate augments Niraparib killing of tumor cells.

Booth, Laurence; Roberts, Jane L; Rais, Rumeesa; Poklepovic, Andrew; Dent, Paul

Booth, Laurence; Roberts, Jane L; Rais, Rumeesa; Poklepovic, Andrew; Dent, Paul.

Affiliation

Booth L; a Departments of Biochemistry and Molecular Biology , Virginia Commonwealth University , Richmond , VA , USA.
Roberts JL; a Departments of Biochemistry and Molecular Biology , Virginia Commonwealth University , Richmond , VA , USA.
Rais R; a Departments of Biochemistry and Molecular Biology , Virginia Commonwealth University , Richmond , VA , USA.
Poklepovic A; b Medicine , Virginia Commonwealth University , Richmond , VA , USA.
Dent P; a Departments of Biochemistry and Molecular Biology , Virginia Commonwealth University , Richmond , VA , USA.

Cancer Biol Ther ; 19(9): 797-808, 2018.

Article in En | MEDLINE | ID: mdl-29923797

Subject(s)

Indazoles/pharmacology; Piperidines/pharmacology; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology; Valproic Acid/pharmacology; Animals; Autophagy/drug effects; Biomarkers; Cell Line, Tumor; Cell Survival/drug effects; DNA Damage/drug effects; Dose-Response Relationship, Drug; Drug Synergism; Gene Knockdown Techniques; Humans; Mice; Signal Transduction/drug effects

Key words

DNA damage; HDAC; autophagy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Valproic Acid / Poly(ADP-ribose) Polymerase Inhibitors / Indazoles Limits: Animals / Humans Language: En Journal: Cancer Biol Ther Journal subject: NEOPLASIAS / TERAPEUTICA Year: 2018 Type: Article Affiliation country: United States

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