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Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing.
Gerhart, Sarah V; Kellner, Wendy A; Thompson, Christine; Pappalardi, Melissa B; Zhang, Xi-Ping; Montes de Oca, Rocio; Penebre, Elayne; Duncan, Kenneth; Boriack-Sjodin, Ann; Le, BaoChau; Majer, Christina; McCabe, Michael T; Carpenter, Chris; Johnson, Neil; Kruger, Ryan G; Barbash, Olena.
Affiliation
  • Gerhart SV; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Kellner WA; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Thompson C; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Pappalardi MB; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Zhang XP; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Montes de Oca R; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Penebre E; Epizyme, Inc., Cambridge, MA, USA.
  • Duncan K; Epizyme, Inc., Cambridge, MA, USA.
  • Boriack-Sjodin A; Epizyme, Inc., Cambridge, MA, USA.
  • Le B; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Majer C; Epizyme, Inc., Cambridge, MA, USA.
  • McCabe MT; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Carpenter C; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Johnson N; Rubius Therapeutics, Boston, MA, USA.
  • Kruger RG; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
  • Barbash O; Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.
Sci Rep ; 8(1): 9711, 2018 06 26.
Article in En | MEDLINE | ID: mdl-29946150
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Arginine N-Methyltransferases / Nuclear Proteins / RNA Splicing / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins Limits: Humans Language: En Journal: Sci Rep Year: 2018 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Arginine N-Methyltransferases / Nuclear Proteins / RNA Splicing / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins Limits: Humans Language: En Journal: Sci Rep Year: 2018 Type: Article Affiliation country: United States