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Autochthonous acute hepatitis E: treatment with sofosbuvir and ribavirin.
Biliotti, Elisa; Franchi, Cristiana; Spaziante, Martina; Garbuglia, Anna Rosa; Volpicelli, Lorenzo; Palazzo, Donatella; De Angelis, Maurizio; Esvan, Rozenn; Taliani, Gloria.
Affiliation
  • Biliotti E; Department of Clinical Medicine, Clinic of Tropical Medicine, Sapienza University of Rome, Rome, Italy. elisabiliotti@yahoo.it.
  • Franchi C; Department of Clinical Medicine, Clinic of Tropical Medicine, Sapienza University of Rome, Rome, Italy.
  • Spaziante M; Department of Clinical Medicine, Clinic of Tropical Medicine, Sapienza University of Rome, Rome, Italy.
  • Garbuglia AR; Laboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani", Rome, Italy.
  • Volpicelli L; Department of Clinical Medicine, Clinic of Tropical Medicine, Sapienza University of Rome, Rome, Italy.
  • Palazzo D; Department of Clinical Medicine, Clinic of Tropical Medicine, Sapienza University of Rome, Rome, Italy.
  • De Angelis M; Department of Clinical Medicine, Clinic of Tropical Medicine, Sapienza University of Rome, Rome, Italy.
  • Esvan R; Department of Clinical Medicine, Clinic of Tropical Medicine, Sapienza University of Rome, Rome, Italy.
  • Taliani G; Department of Clinical Medicine, Clinic of Tropical Medicine, Sapienza University of Rome, Rome, Italy.
Infection ; 46(5): 725-727, 2018 Oct.
Article in En | MEDLINE | ID: mdl-29946850
INTRODUCTION: Hepatitis E virus (HEV) is an emerging cause of autochthonous-acute-hepatitis and acute-on-chronic-liver-failure in western countries. Treatment is not routinely used, despite ribavirin has a good antiviral effect. In vitro sofosbuvir inhibits HEV replication, but clinical data are lacking. CASE REPORT: We report a case of acute-on-chronic-liver-failure due to HEV treated with sofosbuvir and ribavirin. The treatment was capable of rapidly inducing both HCV and HEV viral suppression. CONCLUSION: In conclusion, although more data are required before firm conclusions could be drawn, the combination of sofosbuvir and ribavirin in not immunosuppressed patients with acute hepatitis E may be able to clear HEV infection.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ribavirin / Hepatitis E / Sofosbuvir Type of study: Diagnostic_studies Limits: Humans / Male / Middle aged Language: En Journal: Infection Year: 2018 Type: Article Affiliation country: Italy
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ribavirin / Hepatitis E / Sofosbuvir Type of study: Diagnostic_studies Limits: Humans / Male / Middle aged Language: En Journal: Infection Year: 2018 Type: Article Affiliation country: Italy