Inducing protein-protein interactions with molecular glues.

Che, Ye; Gilbert, Adam M; Shanmugasundaram, Veerabahu; Noe, Mark C

Che, Ye; Gilbert, Adam M; Shanmugasundaram, Veerabahu; Noe, Mark C.

Affiliation

Che Y; Discovery Sciences, Medicine Design, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States.
Gilbert AM; Discovery Sciences, Medicine Design, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States.
Shanmugasundaram V; Discovery Sciences, Medicine Design, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States.
Noe MC; Discovery Sciences, Medicine Design, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: mark.c.noe@pfizer.com.

Bioorg Med Chem Lett ; 28(15): 2585-2592, 2018 08 15.

Article in En | MEDLINE | ID: mdl-29980357

Subject(s)

Adhesives/pharmacology; Biological Products/pharmacology; Allosteric Regulation/drug effects; Drug Discovery; Humans; Ligands; Protein Binding; Proteolysis; Receptors, Cytoplasmic and Nuclear/drug effects; Receptors, Cytoplasmic and Nuclear/metabolism

Key words

Induced protein interactions; Molecular glues; Targeted protein degradation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biological Products / Adhesives Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Type: Article Affiliation country: United States

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