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No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice.
Iyer, Vivek; Boroviak, Katharina; Thomas, Mark; Doe, Brendan; Riva, Laura; Ryder, Edward; Adams, David J.
Affiliation
  • Iyer V; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.
  • Boroviak K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.
  • Thomas M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.
  • Doe B; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.
  • Riva L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.
  • Ryder E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.
  • Adams DJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.
PLoS Genet ; 14(7): e1007503, 2018 07.
Article in En | MEDLINE | ID: mdl-29985941
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mutagenesis / Monophenol Monooxygenase / CRISPR-Cas Systems / Gene Editing / Whole Genome Sequencing Limits: Animals Language: En Journal: PLoS Genet Journal subject: GENETICA Year: 2018 Type: Article Affiliation country: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mutagenesis / Monophenol Monooxygenase / CRISPR-Cas Systems / Gene Editing / Whole Genome Sequencing Limits: Animals Language: En Journal: PLoS Genet Journal subject: GENETICA Year: 2018 Type: Article Affiliation country: United kingdom