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More is not always better: finding the right trade-off between affinity and selectivity of a G-quadruplex ligand.
Zuffo, Michela; Guédin, Aurore; Leriche, Emma-Dune; Doria, Filippo; Pirota, Valentina; Gabelica, Valérie; Mergny, Jean-Louis; Freccero, Mauro.
Affiliation
  • Zuffo M; Dipartimento di Chimica, Università di Pavia, Pavia 27100, Italy.
  • Guédin A; ARNA Laboratory, Université de Bordeaux, Inserm U1212, CNRS UMR5320, Institut Européen de Chimie Biologie (IECB), Pessac 33607, France.
  • Leriche ED; ARNA Laboratory, Université de Bordeaux, Inserm U1212, CNRS UMR5320, Institut Européen de Chimie Biologie (IECB), Pessac 33607, France.
  • Doria F; Dipartimento di Chimica, Università di Pavia, Pavia 27100, Italy.
  • Pirota V; Dipartimento di Chimica, Università di Pavia, Pavia 27100, Italy.
  • Gabelica V; ARNA Laboratory, Université de Bordeaux, Inserm U1212, CNRS UMR5320, Institut Européen de Chimie Biologie (IECB), Pessac 33607, France.
  • Mergny JL; ARNA Laboratory, Université de Bordeaux, Inserm U1212, CNRS UMR5320, Institut Européen de Chimie Biologie (IECB), Pessac 33607, France.
  • Freccero M; Institute of Biophysics, AS CR, Brno 61265, Czech Republic.
Nucleic Acids Res ; 46(19): e115, 2018 11 02.
Article in En | MEDLINE | ID: mdl-29986058
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: G-Quadruplexes / Imides / Intercalating Agents / Ligands / Naphthalenes Type of study: Diagnostic_studies Language: En Journal: Nucleic Acids Res Year: 2018 Type: Article Affiliation country: Italy
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: G-Quadruplexes / Imides / Intercalating Agents / Ligands / Naphthalenes Type of study: Diagnostic_studies Language: En Journal: Nucleic Acids Res Year: 2018 Type: Article Affiliation country: Italy