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Salmonella exploits host Rho GTPase signalling pathways through the phosphatase activity of SopB.
Truong, Dorothy; Boddy, Kirsten C; Canadien, Veronica; Brabant, Danielle; Fairn, Gregory D; D'Costa, Vanessa M; Coyaud, Etienne; Raught, Brian; Pérez-Sala, Dolores; Park, Wei Sun; Heo, Won Do; Grinstein, Sergio; Brumell, John H.
Affiliation
  • Truong D; Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.
  • Boddy KC; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Canadien V; Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.
  • Brabant D; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
  • Fairn GD; Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.
  • D'Costa VM; Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.
  • Coyaud E; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
  • Raught B; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.
  • Pérez-Sala D; Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.
  • Park WS; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Heo WD; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Grinstein S; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
  • Brumell JH; Department of Structural and Chemical Biology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Cell Microbiol ; 20(10): e12938, 2018 10.
Article in En | MEDLINE | ID: mdl-30010242
ABSTRACT
Salmonella uses Type 3 secretion systems (T3SSs) to deliver virulence factors, called effectors, into host cells during infection. The T3SS effectors promote invasion into host cells and the generation of a replicative niche. SopB is a T3SS effector that plays an important role in Salmonella pathogenesis through its lipid phosphatase activity. Here, we show that SopB mediates the recruitment of Rho GTPases (RhoB, RhoD, RhoH, and RhoJ) to bacterial invasion sites. RhoJ contributes to Salmonella invasion, and RhoB and RhoH play an important role in Akt activation. R-Ras1 also contributes to SopB-dependent Akt activation by promoting the localised production of PI(3,4)P2 /PI(3,4,5)P3 . Our studies reveal new signalling factors involved in SopB-dependent Salmonella infection.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salmonella Infections / Salmonella typhimurium / Bacterial Proteins / Rho GTP-Binding Proteins / Type III Secretion Systems Limits: Humans Language: En Journal: Cell Microbiol Journal subject: MICROBIOLOGIA Year: 2018 Type: Article Affiliation country: Canada
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salmonella Infections / Salmonella typhimurium / Bacterial Proteins / Rho GTP-Binding Proteins / Type III Secretion Systems Limits: Humans Language: En Journal: Cell Microbiol Journal subject: MICROBIOLOGIA Year: 2018 Type: Article Affiliation country: Canada