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Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Jimenez-Vargas, Nestor N; Pattison, Luke A; Zhao, Peishen; Lieu, TinaMarie; Latorre, Rocco; Jensen, Dane D; Castro, Joel; Aurelio, Luigi; Le, Giang T; Flynn, Bernard; Herenbrink, Carmen Klein; Yeatman, Holly R; Edgington-Mitchell, Laura; Porter, Christopher J H; Halls, Michelle L; Canals, Meritxell; Veldhuis, Nicholas A; Poole, Daniel P; McLean, Peter; Hicks, Gareth A; Scheff, Nicole; Chen, Elyssa; Bhattacharya, Aditi; Schmidt, Brian L; Brierley, Stuart M; Vanner, Stephen J; Bunnett, Nigel W.
Affiliation
  • Jimenez-Vargas NN; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON K7L 2V7, Canada.
  • Pattison LA; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
  • Zhao P; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
  • Lieu T; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
  • Latorre R; Department of Surgery, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032.
  • Jensen DD; Department of Pharmacology, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032.
  • Castro J; Department of Surgery, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032.
  • Aurelio L; Department of Pharmacology, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032.
  • Le GT; Visceral Pain Research Group, Human Physiology, Centre for Neuroscience, Flinders University, Adelaide, SA 5000, Australia.
  • Flynn B; Centre for Nutrition and Gastrointestinal Diseases, Discipline of Medicine, University of Adelaide, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia.
  • Herenbrink CK; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
  • Yeatman HR; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
  • Edgington-Mitchell L; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
  • Porter CJH; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
  • Halls ML; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
  • Canals M; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
  • Veldhuis NA; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
  • Poole DP; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
  • McLean P; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
  • Hicks GA; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
  • Scheff N; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
  • Chen E; Department of Anatomy and Neuroscience, University of Melbourne, Parkville, VIC 3010, Australia.
  • Bhattacharya A; Gastrointestinal Drug Discovery Unit, Takeda Pharmaceuticals, Inc., Cambridge, MA 02139.
  • Schmidt BL; Gastrointestinal Drug Discovery Unit, Takeda Pharmaceuticals, Inc., Cambridge, MA 02139.
  • Brierley SM; Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
  • Vanner SJ; Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
  • Bunnett NW; Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Proc Natl Acad Sci U S A ; 115(31): E7438-E7447, 2018 07 31.
Article in En | MEDLINE | ID: mdl-30012612
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endosomes / Signal Transduction / Irritable Bowel Syndrome / Receptor, PAR-2 / Chronic Pain Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Type: Article Affiliation country: Canada
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endosomes / Signal Transduction / Irritable Bowel Syndrome / Receptor, PAR-2 / Chronic Pain Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Type: Article Affiliation country: Canada