Controllable protein phase separation and modular recruitment to form responsive membraneless organelles.

Schuster, Benjamin S; Reed, Ellen H; Parthasarathy, Ranganath; Jahnke, Craig N; Caldwell, Reese M; Bermudez, Jessica G; Ramage, Holly; Good, Matthew C; Hammer, Daniel A

Schuster, Benjamin S; Reed, Ellen H; Parthasarathy, Ranganath; Jahnke, Craig N; Caldwell, Reese M; Bermudez, Jessica G; Ramage, Holly; Good, Matthew C; Hammer, Daniel A.

Affiliation

Schuster BS; Department of Bioengineering, University of Pennsylvania, 210 S. 33rd St, Philadelphia, PA, 19104, USA.
Reed EH; Department of Chemical and Biomolecular Engineering, University of Pennsylvania, 220 S. 33rd St., Philadelphia, PA, 19104, USA.
Parthasarathy R; Department of Bioengineering, University of Pennsylvania, 210 S. 33rd St, Philadelphia, PA, 19104, USA.
Jahnke CN; Department of Chemical and Biomolecular Engineering, University of Pennsylvania, 220 S. 33rd St., Philadelphia, PA, 19104, USA.
Caldwell RM; Department of Cell and Developmental Biology, University of Pennsylvania, 421 Curie Blvd., Philadelphia, PA, 19104, USA.
Bermudez JG; Department of Bioengineering, University of Pennsylvania, 210 S. 33rd St, Philadelphia, PA, 19104, USA.
Ramage H; Department of Microbiology, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA, 19104, USA.
Good MC; Department of Bioengineering, University of Pennsylvania, 210 S. 33rd St, Philadelphia, PA, 19104, USA. mattgood@pennmedicine.upenn.edu.
Hammer DA; Department of Cell and Developmental Biology, University of Pennsylvania, 421 Curie Blvd., Philadelphia, PA, 19104, USA. mattgood@pennmedicine.upenn.edu.

Nat Commun ; 9(1): 2985, 2018 07 30.

Article in En | MEDLINE | ID: mdl-30061688

Subject(s)

Cytoplasmic Granules/chemistry; Intrinsically Disordered Proteins/chemistry; Organelles/chemistry; Amino Acid Motifs; Animals; Caenorhabditis elegans; Cell Line, Tumor; Cloning, Molecular; Cytoplasm/chemistry; Gene Expression Regulation, Developmental; HEK293 Cells; HeLa Cells; Humans; Oxidation-Reduction; Permeability; Protein Domains; Protein Engineering/methods; Recombinant Proteins/chemistry; Solubility; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Xenopus

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organelles / Cytoplasmic Granules / Intrinsically Disordered Proteins Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2018 Type: Article Affiliation country: United States

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