Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma.

Seto, Anita G; Beatty, Xuan; Lynch, Joshua M; Hermreck, Melanie; Tetzlaff, Michael; Duvic, Madeleine; Jackson, Aimee L

Seto, Anita G; Beatty, Xuan; Lynch, Joshua M; Hermreck, Melanie; Tetzlaff, Michael; Duvic, Madeleine; Jackson, Aimee L.

Affiliation

Seto AG; miRagen Therapeutics, Inc., Boulder, CO, USA.
Beatty X; miRagen Therapeutics, Inc., Boulder, CO, USA.
Lynch JM; miRagen Therapeutics, Inc., Boulder, CO, USA.
Hermreck M; miRagen Therapeutics, Inc., Boulder, CO, USA.
Tetzlaff M; Section of Dermatopathology, Department of Pathology, Department of Translational and Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Duvic M; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jackson AL; miRagen Therapeutics, Inc., Boulder, CO, USA.

Br J Haematol ; 183(3): 428-444, 2018 11.

Article in En | MEDLINE | ID: mdl-30125933

Subject(s)

HTLV-I Infections; Human T-lymphotropic virus 1; Lymphoma, T-Cell, Cutaneous; MicroRNAs/antagonists & inhibitors; Oligonucleotides/pharmacology; RNA, Neoplasm/antagonists & inhibitors; Cell Line, Tumor; Cell Survival; Clinical Trials, Phase I as Topic; Disease-Free Survival; Female; HTLV-I Infections/drug therapy; HTLV-I Infections/metabolism; HTLV-I Infections/mortality; HTLV-I Infections/pathology; Humans; Lymphoma, T-Cell, Cutaneous/drug therapy; Lymphoma, T-Cell, Cutaneous/metabolism; Lymphoma, T-Cell, Cutaneous/mortality; Lymphoma, T-Cell, Cutaneous/pathology; Male; MicroRNAs/metabolism; RNA, Neoplasm/metabolism; Survival Rate

Key words

Sézary syndrome; cobomarsen; cutaneous T-cell lymphoma; miR-155; mycosis fungoides

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides / RNA, Neoplasm / Human T-lymphotropic virus 1 / HTLV-I Infections / Lymphoma, T-Cell, Cutaneous / MicroRNAs Limits: Female / Humans / Male Language: En Journal: Br J Haematol Year: 2018 Type: Article Affiliation country: United States

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