Simplified Aztreonam Dosing in Patients with End-Stage Renal Disease: Results of a Monte Carlo Simulation.
Antimicrob Agents Chemother
; 62(11)2018 11.
Article
in En
| MEDLINE
| ID: mdl-30150467
ABSTRACT
The manufacturer-recommended aztreonam dosing for patients with creatinine clearance values of <10 ml/min/1.73 m2 is complex. It is not known whether simpler posthemodialysis dosing administered once daily or thrice weekly can reliably achieve pharmacodynamic goals. We found that 1 or 2 g administered once daily after hemodialysis had >90% probability of target attainment up to MICs of 4 or 8 mg/liter, respectively. Thrice-weekly dosing should generally be avoided, except in nonsevere infections with MICs of ≤0.5 mg/liter.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aztreonam
/
Kidney Failure, Chronic
/
Anti-Bacterial Agents
Type of study:
Health_economic_evaluation
Limits:
Humans
/
Male
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
2018
Type:
Article
Affiliation country:
United States