Molecular Determinants of Substrate Affinity and Enzyme Activity of a Cytochrome P450<sub>BM3</sub> Variant.

Geronimo, Inacrist; Denning, Catherine A; Heidary, David K; Glazer, Edith C; Payne, Christina M

Molecular Determinants of Substrate Affinity and Enzyme Activity of a Cytochrome P450_BM3 Variant.

Geronimo, Inacrist; Denning, Catherine A; Heidary, David K; Glazer, Edith C; Payne, Christina M.

Affiliation

Geronimo I; Department of Chemical and Materials Engineering, University of Kentucky, Lexington, Kentucky.
Denning CA; Department of Chemistry, University of Kentucky, Lexington, Kentucky.
Heidary DK; Department of Chemistry, University of Kentucky, Lexington, Kentucky.
Glazer EC; Department of Chemistry, University of Kentucky, Lexington, Kentucky. Electronic address: ec.glazer@uky.edu.
Payne CM; Department of Chemical and Materials Engineering, University of Kentucky, Lexington, Kentucky. Electronic address: christy.payne@uky.edu.

Biophys J ; 115(7): 1251-1263, 2018 10 02.

Article in En | MEDLINE | ID: mdl-30224054

Subject(s)

Bacterial Proteins/metabolism; Cytochrome P-450 Enzyme System/metabolism; Molecular Dynamics Simulation; Mutation; NADPH-Ferrihemoprotein Reductase/metabolism; Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Catalytic Domain; Cytochrome P-450 Enzyme System/chemistry; Cytochrome P-450 Enzyme System/genetics; Heme/metabolism; Mutagenesis, Site-Directed; NADPH-Ferrihemoprotein Reductase/chemistry; NADPH-Ferrihemoprotein Reductase/genetics; Protein Binding; Thermodynamics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / NADPH-Ferrihemoprotein Reductase / Cytochrome P-450 Enzyme System / Molecular Dynamics Simulation / Mutation Language: En Journal: Biophys J Year: 2018 Type: Article

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