Chronic hand eczema in Germany: 5-year follow-up data from the CARPE registry.
Contact Dermatitis
; 80(1): 45-53, 2019 Jan.
Article
in En
| MEDLINE
| ID: mdl-30246346
ABSTRACT
BACKGROUND:
The CARPE registry was set up in 2009 to prospectively investigate the management of patients with chronic hand eczema (CHE).OBJECTIVES:
To report comprehensive follow-up data from the CARPE registry. PATIENTS ANDMETHODS:
We investigated sociodemographic and clinical characteristics, provision of medical care, physician-assessed outcomes, and patient-reported outcomes (PROs). Data were collected between 2009 and 2016, with up to 5 years of follow-up, and are reported descriptively.RESULTS:
Overall, 1281 patients were included in the registry (53.7% female). Mean age was 47.0 years. Of the patients, 793 and 231 completed the 2-year follow-up and 5-year follow-up, respectively. At baseline, 5.4% had changed or given up their job because of CHE, the average duration of CHE was 6.1 years, and, in 22.4%, the CHE was severe according to physician global assessment. Systemic treatment (alitretinoin, acitretin, and methotrexate) was prescribed at least once to 39.0% of the patients during the course of the follow-up. Disease severity, quality of life and treatment satisfaction improved over time, and the proportion of patients receiving systemic treatments decreased.CONCLUSIONS:
Under continued dermatological care, substantial improvements in disease severity and PROs over time was achieved during the course of the CARPE registry, even in patients with long-standing and severe hand eczema.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Registries
/
Dermatitis, Allergic Contact
/
Hand Dermatoses
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Contact Dermatitis
Year:
2019
Type:
Article
Affiliation country:
Germany