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Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction.
Unsworth, Amanda J; Bye, Alexander P; Kriek, Neline; Sage, Tanya; Osborne, Ashley A; Donaghy, Dillon; Gibbins, Jonathan M.
Affiliation
  • Unsworth AJ; a Institute for Cardiovascular and Metabolic Research , University of Reading, School of Biological Sciences , Reading , UK.
  • Bye AP; a Institute for Cardiovascular and Metabolic Research , University of Reading, School of Biological Sciences , Reading , UK.
  • Kriek N; a Institute for Cardiovascular and Metabolic Research , University of Reading, School of Biological Sciences , Reading , UK.
  • Sage T; a Institute for Cardiovascular and Metabolic Research , University of Reading, School of Biological Sciences , Reading , UK.
  • Osborne AA; a Institute for Cardiovascular and Metabolic Research , University of Reading, School of Biological Sciences , Reading , UK.
  • Donaghy D; b Department of Microbiology Immunology and Pathology , Colorado State University , Fort Collins , CO , USA.
  • Gibbins JM; a Institute for Cardiovascular and Metabolic Research , University of Reading, School of Biological Sciences , Reading , UK.
Platelets ; 30(6): 762-772, 2019.
Article in En | MEDLINE | ID: mdl-30252580
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Pyridones / Pyrimidinones / Azetidines / Blood Platelets / Antineoplastic Combined Chemotherapy Protocols / Protein Kinase Inhibitors Type of study: Prognostic_studies Limits: Humans Language: En Journal: Platelets Journal subject: HEMATOLOGIA Year: 2019 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Pyridones / Pyrimidinones / Azetidines / Blood Platelets / Antineoplastic Combined Chemotherapy Protocols / Protein Kinase Inhibitors Type of study: Prognostic_studies Limits: Humans Language: En Journal: Platelets Journal subject: HEMATOLOGIA Year: 2019 Type: Article Affiliation country: United kingdom