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A Map-like Micro-Organization of Grid Cells in the Medial Entorhinal Cortex.
Gu, Yi; Lewallen, Sam; Kinkhabwala, Amina A; Domnisoru, Cristina; Yoon, Kijung; Gauthier, Jeffrey L; Fiete, Ila R; Tank, David W.
Affiliation
  • Gu Y; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; Bezos Center for Neural Circuit Dynamics, Princeton University, NJ 08544, USA. Electronic address: guyi.thu@gmail.com.
  • Lewallen S; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; Bezos Center for Neural Circuit Dynamics, Princeton University, NJ 08544, USA.
  • Kinkhabwala AA; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; Bezos Center for Neural Circuit Dynamics, Princeton University, NJ 08544, USA.
  • Domnisoru C; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; Bezos Center for Neural Circuit Dynamics, Princeton University, NJ 08544, USA.
  • Yoon K; Center for Learning and Memory, University of Texas at Austin, Austin, TX 78712, USA; Department of Neuroscience, University of Texas at Austin, Austin, TX 78712, USA.
  • Gauthier JL; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; Bezos Center for Neural Circuit Dynamics, Princeton University, NJ 08544, USA.
  • Fiete IR; Center for Learning and Memory, University of Texas at Austin, Austin, TX 78712, USA; Department of Neuroscience, University of Texas at Austin, Austin, TX 78712, USA.
  • Tank DW; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; Bezos Center for Neural Circuit Dynamics, Princeton University, NJ 08544, USA. Electronic address: dwtank@princeton.edu.
Cell ; 175(3): 736-750.e30, 2018 10 18.
Article in En | MEDLINE | ID: mdl-30270041
ABSTRACT
How the topography of neural circuits relates to their function remains unclear. Although topographic maps exist for sensory and motor variables, they are rarely observed for cognitive variables. Using calcium imaging during virtual navigation, we investigated the relationship between the anatomical organization and functional properties of grid cells, which represent a cognitive code for location during navigation. We found a substantial degree of grid cell micro-organization in mouse medial entorhinal cortex grid cells and modules all clustered anatomically. Within a module, the layout of grid cells was a noisy two-dimensional lattice in which the anatomical distribution of grid cells largely matched their spatial tuning phases. This micro-arrangement of phases demonstrates the existence of a topographical map encoding a cognitive variable in rodents. It contributes to a foundation for evaluating circuit models of the grid cell network and is consistent with continuous attractor models as the mechanism of grid formation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Entorhinal Cortex / Grid Cells Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Year: 2018 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Entorhinal Cortex / Grid Cells Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Year: 2018 Type: Article