Asymmetric Fluorination of Cyclic Tetrasubstituted Alkenes with a Pendant Amide Groups under Dianionic Phase-Transfer Catalysis.
Chem Pharm Bull (Tokyo)
; 66(10): 920-922, 2018.
Article
in En
| MEDLINE
| ID: mdl-30270238
Asymmetric fluorination of cyclic tetrasubstituted alkenes with a pendant amide group was investigated under dianionic phase-transfer catalysis. Fluorination proceeded with high face selectivity, affording the corresponding allylic fluorides with a chiral tetrasubstituted carbon center with up to 97% enantiomeric excess (ee). It should be noted that deprotonative fluorination occurred mainly in preference to intramolecular nucleophilic attack of the amide group.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cycloparaffins
/
Dicarboxylic Acids
/
Halogenation
/
Amides
/
Hydrocarbons, Fluorinated
Language:
En
Journal:
Chem Pharm Bull (Tokyo)
Year:
2018
Type:
Article