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Birth Anomalies in Monozygotic and Dizygotic Twins: Results From the California Twin Registry.
Yu, Yang; Cozen, Wendy; Hwang, Amie E; Cockburn, Myles G; Zadnick, John; Hamilton, Ann S; Mack, Thomas; Figueiredo, Jane C.
Affiliation
  • Yu Y; Department of Preventive Medicine, Keck School of Medicine, University of Southern California.
  • Cozen W; Department of Preventive Medicine, Keck School of Medicine, University of Southern California.
  • Hwang AE; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California.
  • Cockburn MG; Department of Preventive Medicine, Keck School of Medicine, University of Southern California.
  • Zadnick J; Department of Preventive Medicine, Keck School of Medicine, University of Southern California.
  • Hamilton AS; Department of Epidemiology, Colorado School of Public Health and AMC/CancerCure Chair, Cancer Prevention and Control, University of Colorado Cancer Center.
  • Mack T; Department of Preventive Medicine, Keck School of Medicine, University of Southern California.
  • Figueiredo JC; Department of Preventive Medicine, Keck School of Medicine, University of Southern California.
J Epidemiol ; 29(1): 18-25, 2019 Jan 05.
Article in En | MEDLINE | ID: mdl-30270263
BACKGROUND: Inherited factors and maternal behaviors are thought to play an important role in the etiology of several congenital malformations. Twin studies can offer additional evidence regarding the contribution of genetic and lifestyle factors to common birth anomalies, but few large-scale studies have been reported. METHODS: We included data from twins (20,803 pairs) from the population-based California Twin Program. We compared concordance in monozygotic (MZ) to dizygotic (DZ) twins for the following birth anomalies: clubfoot, oral cleft, spina bifida, muscular dystrophy, deafness, cerebral palsy, strabismus, and congenital heart defects. Each birth anomaly was also examined for the associations with birth characteristics (birthweight and birth order) and parental exposures (age, smoking, and parental education). RESULTS: The overall prevalence of any selected birth anomaly in California twins was 38 per 1,000 persons, with a slightly decreasing trend from 1957-1982. For pairwise concordance in 6,752 MZ and 7,326 like-sex DZ twin pairs, high MZ:DZ concordance ratios were observed for clubfoot (CR 5.91; P = 0.043) and strabismus (CR 2.52; P = 0.001). Among the total 20,803 pairs, parental smoking was significantly associated with risk of spina bifida (OR 3.48; 95% CI, 1.48-8.18) and strabismus (OR 1.61; 95% CI, 1.28-2.03). A significant quadratic trend of increasing risk for clubfoot, spina bifida, and strabismus was found when examining whether father smoked, mother smoked, or both parents smoked relative to non-smoking parents (P = 0.029, 0.026, and 0.0005, respectively). CONCLUSIONS: Our results provide evidence for a multifactorial etiology underlying selected birth anomalies. Further research is needed to understand the biological mechanisms.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Congenital Abnormalities / Twins, Dizygotic / Twins, Monozygotic / Diseases in Twins Type of study: Prevalence_studies / Risk_factors_studies Limits: Female / Humans / Male / Newborn Country/Region as subject: America do norte Language: En Journal: J Epidemiol Journal subject: EPIDEMIOLOGIA Year: 2019 Type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Congenital Abnormalities / Twins, Dizygotic / Twins, Monozygotic / Diseases in Twins Type of study: Prevalence_studies / Risk_factors_studies Limits: Female / Humans / Male / Newborn Country/Region as subject: America do norte Language: En Journal: J Epidemiol Journal subject: EPIDEMIOLOGIA Year: 2019 Type: Article