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Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility.
Raj, Towfique; Li, Yang I; Wong, Garrett; Humphrey, Jack; Wang, Minghui; Ramdhani, Satesh; Wang, Ying-Chih; Ng, Bernard; Gupta, Ishaan; Haroutunian, Vahram; Schadt, Eric E; Young-Pearse, Tracy; Mostafavi, Sara; Zhang, Bin; Sklar, Pamela; Bennett, David A; De Jager, Philip L.
Affiliation
  • Raj T; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. towfique.raj@mssm.edu.
  • Li YI; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. towfique.raj@mssm.edu.
  • Wong G; Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.
  • Humphrey J; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Wang M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Ramdhani S; Genetics Institute, University College London, London, UK.
  • Wang YC; Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, UK.
  • Ng B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Gupta I; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Haroutunian V; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Schadt EE; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Young-Pearse T; Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada.
  • Mostafavi S; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
  • Zhang B; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Sklar P; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Bennett DA; James J. Peters VA Medical Center, New York, NY, USA.
  • De Jager PL; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nat Genet ; 50(11): 1584-1592, 2018 11.
Article in En | MEDLINE | ID: mdl-30297968
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Aging / Alternative Splicing / Gene Expression Profiling / Alzheimer Disease Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2018 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Aging / Alternative Splicing / Gene Expression Profiling / Alzheimer Disease Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2018 Type: Article Affiliation country: United States