Plasma YKL-40 levels correlate with the severity of coronary atherosclerosis assessed with the SYNTAX score.
Pol Arch Intern Med
; 128(11): 644-648, 2018 11 30.
Article
in En
| MEDLINE
| ID: mdl-30303489
ABSTRACT
Introduction YKL40 is a protein released locally by inflammatory cells. Thus, it may constitute a biomarker of inflammatory conditions, such as atherosclerosis. Objectives The aim of the study was to determine YKL40 levels in patients with ischemic heart disease and to analyze the correlation of this biomarker with the severity of coronary atherosclerosis. Patients and methods The study included 158 patients 52 with stable ischemic heart disease and 67 with acute coronary syndrome STsegment elevation myocardial infarction (STEMI; n = 47) or non-STsegment elevation myocardial infarction (NSTEMI; n = 20). The control group included 39 individuals without abnormalities in coronary vessels. We evaluated plasma YKL40 levels and their correlation with the severity of coronary atherosclerosis assessed with the SYNTAX score. Results Patients with myocardial infarction had higher plasma YKL40 levels than those with stable ischemic disease (median [range], 235.3 [161.6-366.1] ng/ml vs 61.2 [53.1-83.1] ng/ml; P <0.001) or controls (median [range], 235.3 [161.6-366.1] ng/ml vs 55.7 [51.2-75.2] ng/ml; P <0.001). No differences were found in YKL40 concentrations between STEMI and NSTEMI patients (median [range], 263 [150.3-363.7] ng/ml and 214.9 [163.4-367.6] ng/ml, respectively; P = 0.7). The SYNTAX score in patients with ischemic heart disease correlated positively with YKL40 concentrations (R = 0.34; P <0.001). Conclusions YKL40 can be considered a potential biomarker of coronary atherosclerosis severity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Severity of Illness Index
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Coronary Artery Disease
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Coronary Circulation
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Acute Coronary Syndrome
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Chitinase-3-Like Protein 1
Type of study:
Observational_studies
Limits:
Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Pol Arch Intern Med
Year:
2018
Type:
Article