Phenotypic Screens Reveal Posaconazole as a Rapidly Acting Amebicidal Combination Partner for Treatment of Primary Amoebic Meningoencephalitis.

Colon, Beatrice L; Rice, Christopher A; Guy, R Kiplin; Kyle, Dennis E

Colon, Beatrice L; Rice, Christopher A; Guy, R Kiplin; Kyle, Dennis E.

Affiliation

Colon BL; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa.
Rice CA; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens.
Guy RK; Department of Global Health, College of Public Health, University of South Florida, Tampa.
Kyle DE; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens.

J Infect Dis ; 219(7): 1095-1103, 2019 03 15.

Article in En | MEDLINE | ID: mdl-30358879

Subject(s)

Antiprotozoal Agents/pharmacology; Central Nervous System Protozoal Infections/drug therapy; Drug Discovery/methods; Naegleria fowleri/drug effects; Triazoles/pharmacology; Amphotericin B/pharmacology; Amphotericin B/therapeutic use; Animals; Antiprotozoal Agents/therapeutic use; Azithromycin/pharmacology; Azithromycin/therapeutic use; Disease Models, Animal; Drug Combinations; Drug Synergism; Female; Fluconazole/pharmacology; Fluconazole/therapeutic use; Humans; Inhibitory Concentration 50; Mice; Phenotype; Time Factors; Triazoles/therapeutic use; United States; United States Food and Drug Administration

Key words

Naegleria fowleri; azithromycin; drug discovery; miltefosine; phenotypic screen; posaconazole; primary amoebic meningoencephalitis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazoles / Naegleria fowleri / Central Nervous System Protozoal Infections / Drug Discovery / Antiprotozoal Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Country/Region as subject: America do norte Language: En Journal: J Infect Dis Year: 2019 Type: Article

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