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Reduced cortical thickness in Heschl's gyrus as an in vivo marker for human primary auditory cortex.
Zoellner, Simeon; Benner, Jan; Zeidler, Bettina; Seither-Preisler, Annemarie; Christiner, Markus; Seitz, Angelika; Goebel, Rainer; Heinecke, Armin; Wengenroth, Martina; Blatow, Maria; Schneider, Peter.
Affiliation
  • Zoellner S; Department of Neurology, Section of Biomagnetism, University of Heidelberg Medical School, Heidelberg, Germany.
  • Benner J; Department of Neuroradiology, University of Heidelberg Medical School, Heidelberg, Germany.
  • Zeidler B; Department of Neuroradiology, University of Heidelberg Medical School, Heidelberg, Germany.
  • Seither-Preisler A; Department of Neuroradiology, University of Heidelberg Medical School, Heidelberg, Germany.
  • Christiner M; Institute of Systematic Musicology, University of Hamburg, Hamburg, Germany.
  • Seitz A; Centre for Systematic Musicology, University of Graz, Graz, Austria.
  • Goebel R; BioTechMed, Graz, Austria.
  • Heinecke A; Department of Linguistics, Unit for Language Learning and Teaching Research, University of Vienna, Vienna, Austria.
  • Wengenroth M; Department of Phoniatrics and Pedaudiology, University of Heidelberg Medical School, Heidelberg, Germany.
  • Blatow M; Department of Cognitive Neuroscience, Faculty of Psychology, Universiteit Maastricht, Maastricht, The Netherlands.
  • Schneider P; Department of Cognitive Neuroscience, Faculty of Psychology, Universiteit Maastricht, Maastricht, The Netherlands.
Hum Brain Mapp ; 40(4): 1139-1154, 2019 03.
Article in En | MEDLINE | ID: mdl-30367737
ABSTRACT
The primary auditory cortex (PAC) is located in the region of Heschl's gyrus (HG), as confirmed by histological, cytoarchitectonical, and neurofunctional studies. Applying cortical thickness (CTH) analysis based on high-resolution magnetic resonance imaging (MRI) and magnetoencephalography (MEG) in 60 primary school children and 60 adults, we investigated the CTH distribution of left and right auditory cortex (AC) and primary auditory source activity at the group and individual level. Both groups showed contoured regions of reduced auditory cortex (redAC) along the mediolateral extension of HG, illustrating large inter-individual variability with respect to shape, localization, and lateralization. In the right hemisphere, redAC localized more within the medial portion of HG, extending typically across HG duplications. In the left hemisphere, redAC was distributed significantly more laterally, reaching toward the anterolateral portion of HG. In both hemispheres, redAC was found to be significantly thinner (mean CTH of 2.34 mm) as compared to surrounding areas (2.99 mm). This effect was more dominant in the right hemisphere rather than in the left one. Moreover, localization of the primary component of auditory evoked activity (P1), as measured by MEG in response to complex harmonic sounds, strictly co-localized with redAC. This structure-function link was found consistently at the group and individual level, suggesting PAC to be represented by areas of reduced cortex in HG. Thus, we propose reduced CTH as an in vivo marker for identifying shape and localization of PAC in the individual brain.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Auditory Cortex Limits: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Language: En Journal: Hum Brain Mapp Journal subject: CEREBRO Year: 2019 Type: Article Affiliation country: Germany

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Auditory Cortex Limits: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Language: En Journal: Hum Brain Mapp Journal subject: CEREBRO Year: 2019 Type: Article Affiliation country: Germany