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The sympathomimetic agonist mirabegron did not lower JAK2-V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms: results of phase II study SAKK 33/14.
Drexler, Beatrice; Passweg, Jakob R; Tzankov, Alexandar; Bigler, Martin; Theocharides, Alexandre Pa; Cantoni, Nathan; Keller, Peter; Stussi, Georg; Ruefer, Axel; Benz, Rudolf; Favre, Geneviève; Lundberg, Pontus; Nienhold, Ronny; Fuhrer, Andrea; Biaggi, Christine; Manz, Markus G; Bargetzi, Mario; Mendez-Ferrer, Simon; Skoda, Radek C.
Affiliation
  • Drexler B; Division of Hematology, University Hospital Basel and University of Basel, Switzerland.
  • Passweg JR; Division of Hematology, University Hospital Basel and University of Basel, Switzerland jakob.passweg@usb.ch.
  • Tzankov A; Institute of Pathology, University Hospital Basel and University of Basel, Switzerland.
  • Bigler M; Swiss Group for Clinical Cancer Research, Bern, Switzerland.
  • Theocharides AP; Hematology and Oncology, University Hospital Zurich and University of Zurich, Switzerland.
  • Cantoni N; Oncology, Hematology & Transfusion Medicine, Kantonsspital Aarau AG, Switzerland.
  • Keller P; University Clinic of Hematology and Central Hematology Laboratory, University Hospital Bern, Switzerland.
  • Stussi G; Clinic of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
  • Ruefer A; Departement Medizin, Luzerner Kantonsspital, Switzerland.
  • Benz R; Kantonsspital Muensterlingen, Switzerland.
  • Favre G; Cantonal Hospital Liestal, Switzerland.
  • Lundberg P; Division of Hematology, University Hospital Basel and University of Basel, Switzerland.
  • Nienhold R; Department of Biomedicine, Experimental Hematology, University Hospital Basel and University of Basel, Switzerland.
  • Fuhrer A; Swiss Group for Clinical Cancer Research, Bern, Switzerland.
  • Biaggi C; Swiss Group for Clinical Cancer Research, Bern, Switzerland.
  • Manz MG; Hematology and Oncology, University Hospital Zurich and University of Zurich, Switzerland.
  • Bargetzi M; Oncology, Hematology & Transfusion Medicine, Kantonsspital Aarau AG, Switzerland.
  • Mendez-Ferrer S; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Department of Haematology, University of Cambridge, and National Health Service Blood and Transplant, Cambridge, UK.
  • Skoda RC; Department of Biomedicine, Experimental Hematology, University Hospital Basel and University of Basel, Switzerland radek.skoda@unibas.ch.
Haematologica ; 104(4): 710-716, 2019 04.
Article in En | MEDLINE | ID: mdl-30409796
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reticulin / Sympathomimetics / Thiazoles / Hematologic Neoplasms / Mutation, Missense / Janus Kinase 2 / Nestin / Acetanilides / Myeloproliferative Disorders Limits: Adult / Animals / Female / Humans / Male / Middle aged Language: En Journal: Haematologica Year: 2019 Type: Article Affiliation country: Switzerland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reticulin / Sympathomimetics / Thiazoles / Hematologic Neoplasms / Mutation, Missense / Janus Kinase 2 / Nestin / Acetanilides / Myeloproliferative Disorders Limits: Adult / Animals / Female / Humans / Male / Middle aged Language: En Journal: Haematologica Year: 2019 Type: Article Affiliation country: Switzerland