CYP2D6 as a treatment decision aid for ER-positive non-metastatic breast cancer patients: a systematic review with accompanying clinical practice guidelines.

Drögemöller, Britt I; Wright, Galen E B; Shih, Joanne; Monzon, Jose G; Gelmon, Karen A; Ross, Colin J D; Amstutz, Ursula; Carleton, Bruce C

Drögemöller, Britt I; Wright, Galen E B; Shih, Joanne; Monzon, Jose G; Gelmon, Karen A; Ross, Colin J D; Amstutz, Ursula; Carleton, Bruce C.

Affiliation

Drögemöller BI; BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Wright GEB; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
Shih J; BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Monzon JG; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Gelmon KA; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
Ross CJD; Tom Baker Cancer Centre, Calgary, AB, Canada.
Amstutz U; BC Cancer Agency and University of British Columbia, Vancouver, BC, Canada.
Carleton BC; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.

Breast Cancer Res Treat ; 173(3): 521-532, 2019 Feb.

Article in En | MEDLINE | ID: mdl-30411242

Subject(s)

Breast Neoplasms/genetics; Breast Neoplasms/therapy; Cytochrome P-450 CYP2D6/genetics; Genetic Variation; Receptors, Estrogen/genetics; Alleles; Antineoplastic Agents, Hormonal/pharmacology; Antineoplastic Agents, Hormonal/therapeutic use; Biomarkers, Tumor; Breast Neoplasms/diagnosis; Clinical Decision-Making; Confounding Factors, Epidemiologic; Cytochrome P-450 CYP2D6 Inhibitors/pharmacology; Cytochrome P-450 CYP2D6 Inhibitors/therapeutic use; Disease Management; Female; Genotype; Humans; Pharmacogenetics; Practice Guidelines as Topic; Prognosis; Receptors, Estrogen/metabolism; Tamoxifen/pharmacology; Tamoxifen/therapeutic use

Key words

CYP2D6; Clinical practice guidelines; Pharmacogenomics; Systematic review; Tamoxifen

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Variation / Breast Neoplasms / Receptors, Estrogen / Cytochrome P-450 CYP2D6 Type of study: Diagnostic_studies / Guideline / Prognostic_studies / Systematic_reviews Limits: Female / Humans Language: En Journal: Breast Cancer Res Treat Year: 2019 Type: Article Affiliation country: Canada

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