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A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium.
Oppedal, Ketil; Ferreira, Daniel; Cavallin, Lena; Lemstra, Afina W; Ten Kate, Mara; Padovani, Alessandro; Rektorova, Irena; Bonanni, Laura; Wahlund, Lars-Olof; Engedal, Knut; Nobili, Flavio; Kramberger, Milica; Taylor, John-Paul; Hort, Jakub; Snædal, Jon; Blanc, Frederic; Walker, Zuzana; Antonini, Angelo; Westman, Eric; Aarsland, Dag.
Affiliation
  • Oppedal K; Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway; Department of Radiology, Stavanger University Hospital, Stavanger, Norway.
  • Ferreira D; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
  • Cavallin L; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Radiology, Karolinska University Hospital, Stockholm, Sweden.
  • Lemstra AW; Department of Neurology and Alzheimercenter, VU Universisty Medical Center, Amsterdam, Netherlands.
  • Ten Kate M; Department of Neurology and Alzheimercenter, VU Universisty Medical Center, Amsterdam, Netherlands.
  • Padovani A; Neurology Unit, Department o Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
  • Rektorova I; 1(st) Department of Neurology, Medical Faculty, St. Anne's Hospital and CEITEC, Masaryk University, Brno, Czech Republic.
  • Bonanni L; Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d'Annunzio of Chieti-Pescara, Chieti, Italy.
  • Wahlund LO; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
  • Engedal K; Norwegian Advisory Unit for Ageing and Health, Vestfold Hospital Trust and Oslo University Hospital, Oslo, Norway.
  • Nobili F; Department of Neuroscience (DINOGMI), University of Genoa and Neurology Clinics, Polyclinic San Martino Hospital, Genoa, Italy.
  • Kramberger M; Department of Neurology, University Medical Centre Ljubljana, Medical faculty, University of Ljubljana, Slovenia.
  • Taylor JP; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Hort J; Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
  • Snædal J; Landspitali University Hospital, Reykjavik, Iceland.
  • Blanc F; Day Hospital of Geriatrics, Memory Resource and Research Centre (CM2R) of Strasbourg, Department of Geriatrics, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; University of Strasbourg and French National Centre for Scientific Research (CNRS), ICube Laboratory and Fédération de Médecine T
  • Walker Z; University College London, London & Essex Partnership University NHS Foundation Trust, United Kingdom.
  • Antonini A; Department of Neuroscience, University of Padua, Padua & Fondazione Ospedale San Camillo, Venezia, Venice, Italy.
  • Westman E; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Aarsland D; Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Electronic address: daarsland@gmail.com.
Alzheimers Dement ; 15(3): 400-409, 2019 03.
Article in En | MEDLINE | ID: mdl-30439333
ABSTRACT

INTRODUCTION:

We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB).

METHODS:

In this multicentre study, we included a total of 333 patients with DLB, 352 patients with Alzheimer's disease (AD), and 233 normal controls and used medial temporal lobe atrophy, posterior atrophy, and frontal atrophy (GCA-F) visual rating scales. Patients were classified according to four atrophy patterns.

RESULTS:

Patients with DLB had higher scores on all the three atrophy scales than normal controls but had less medial temporal lobe atrophy than those with AD (all P values < .001). A signature hippocampal-sparing pattern of regional atrophy was observed in DLB. The magnetic resonance imaging measures showed 65% ability to discriminate between DLB and AD and marginally contributed to the discrimination over and above the core clinical features.

DISCUSSION:

The most common pattern of atrophy of DLB was hippocampal-sparing. Future studies should explore whether comorbid AD pathology underlies the atrophy patterns seen in DLB.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cerebral Cortex / Lewy Body Disease Type of study: Diagnostic_studies / Observational_studies Limits: Aged / Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Alzheimers Dement Year: 2019 Type: Article Affiliation country: Norway
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cerebral Cortex / Lewy Body Disease Type of study: Diagnostic_studies / Observational_studies Limits: Aged / Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Alzheimers Dement Year: 2019 Type: Article Affiliation country: Norway