Membrane-enriched solute carrier family 2 member 1 (SLC2A1/GLUT1) in psoriatic keratinocytes confers sensitivity to 2-deoxy-D-glucose (2-DG) treatment.

Huang, Xiaoyan; Chen, Junchen; Zeng, Weiqi; Wu, Xiang; Chen, Mingliang; Chen, Xiang

Huang, Xiaoyan; Chen, Junchen; Zeng, Weiqi; Wu, Xiang; Chen, Mingliang; Chen, Xiang.

Affiliation

Huang X; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chen J; Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, Hunan, China.
Zeng W; Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China.
Wu X; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chen M; Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, Hunan, China.
Chen X; Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China.

Exp Dermatol ; 28(2): 198-201, 2019 02.

Article in En | MEDLINE | ID: mdl-30480843

Subject(s)

Deoxyglucose/pharmacology; Glucose Transporter Type 1/metabolism; Keratinocytes/metabolism; Psoriasis/metabolism; Animals; Biological Transport; Cell Membrane/metabolism; Cell Proliferation; Epidermal Cells/metabolism; Female; Glucose/metabolism; Glucose Transporter Type 4/metabolism; Glycolysis; Humans; Keratinocytes/cytology; Mice; Mice, Inbred BALB C; Psoriasis/chemically induced; Treatment Outcome

Key words

2-DG; glucose; glucose metabolism; imiquimod; psoriasis; therapy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psoriasis / Keratinocytes / Deoxyglucose / Glucose Transporter Type 1 Type of study: Diagnostic_studies Limits: Animals / Female / Humans Language: En Journal: Exp Dermatol Journal subject: DERMATOLOGIA Year: 2019 Type: Article Affiliation country: China

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