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Development of a Human iPSC Cardiomyocyte-Based Scoring System for Cardiac Hazard Identification in Early Drug Safety De-risking.
Kopljar, Ivan; Lu, Hua Rong; Van Ammel, Karel; Otava, Martin; Tekle, Fetene; Teisman, Ard; Gallacher, David J.
Affiliation
  • Kopljar I; Global Safety Pharmacology, Non-Clinical Safety, Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium. Electronic address: ikopljar@its.jnj.com.
  • Lu HR; Global Safety Pharmacology, Non-Clinical Safety, Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium. Electronic address: hlu@its.jnj.com.
  • Van Ammel K; Global Safety Pharmacology, Non-Clinical Safety, Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Otava M; Statistics and Decision Sciences, Quantitative Sciences, Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Tekle F; Statistics and Decision Sciences, Quantitative Sciences, Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Teisman A; Global Safety Pharmacology, Non-Clinical Safety, Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Gallacher DJ; Global Safety Pharmacology, Non-Clinical Safety, Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium.
Stem Cell Reports ; 11(6): 1365-1377, 2018 12 11.
Article in En | MEDLINE | ID: mdl-30540961
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocytes, Cardiac / Drug-Related Side Effects and Adverse Reactions / Induced Pluripotent Stem Cells Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Stem Cell Reports Year: 2018 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocytes, Cardiac / Drug-Related Side Effects and Adverse Reactions / Induced Pluripotent Stem Cells Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Stem Cell Reports Year: 2018 Type: Article