Arctium lappa L. root extract induces cell death via mitochondrial-mediated caspase-dependent apoptosis in Jurkat human leukemic T cells.

Gurunanselage Don, Ravini Ayoddhia Sirilal; Yap, Michelle Khai Khun

Gurunanselage Don, Ravini Ayoddhia Sirilal; Yap, Michelle Khai Khun.

Affiliation

Gurunanselage Don RAS; School of Science, Monash University Malaysia, 47500, Jalan Lagoon Selatan, Bandar Sunway, Malaysia.
Yap MKK; School of Science, Monash University Malaysia, 47500, Jalan Lagoon Selatan, Bandar Sunway, Malaysia. Electronic address: yap.michelle@monash.edu.

Biomed Pharmacother ; 110: 918-929, 2019 Feb.

Article in En | MEDLINE | ID: mdl-30572196

Subject(s)

Antineoplastic Agents, Phytogenic/pharmacology; Arctium; Caspase 3/metabolism; Caspase 7/metabolism; Mitochondria/drug effects; Plant Extracts/pharmacology; 3T3 Cells; Animals; Antineoplastic Agents, Phytogenic/isolation & purification; Apoptosis/drug effects; Apoptosis/physiology; Cell Death/drug effects; Cell Death/physiology; Dose-Response Relationship, Drug; Enzyme Activation/drug effects; Enzyme Activation/physiology; HeLa Cells; Humans; Jurkat Cells; MCF-7 Cells; Membrane Potential, Mitochondrial/drug effects; Membrane Potential, Mitochondrial/physiology; Mice; Mitochondria/enzymology; Plant Extracts/isolation & purification; Plant Roots

Key words

Antiproliferation; Apoptosis; Arctium lappa root extract; Caspase; LCESIMS; Mitochondrial membrane potential

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Extracts / Arctium / Caspase 3 / Caspase 7 / Mitochondria / Antineoplastic Agents, Phytogenic Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biomed Pharmacother Year: 2019 Type: Article Affiliation country: Malaysia

Fulltext

XML

PubMed Links

Search on Google