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Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction.
Bum-Erdene, Khuchtumur; Zhou, Donghui; Gonzalez-Gutierrez, Giovanni; Ghozayel, Mona K; Si, Yubing; Xu, David; Shannon, Harlan E; Bailey, Barbara J; Corson, Timothy W; Pollok, Karen E; Wells, Clark D; Meroueh, Samy O.
Affiliation
  • Bum-Erdene K; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Zhou D; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Gonzalez-Gutierrez G; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA.
  • Ghozayel MK; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Si Y; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Xu D; Department of BioHealth Informatics, Indiana University School of Informatics and Computing, Indianapolis, IN 46202, USA.
  • Shannon HE; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Bailey BJ; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Corson TW; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Pollok KE; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Wells CD; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Meroueh SO; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address: smeroueh@iu.edu.
Cell Chem Biol ; 26(3): 378-389.e13, 2019 03 21.
Article in En | MEDLINE | ID: mdl-30581134
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Cysteine / Adaptor Proteins, Signal Transducing / DNA-Binding Proteins / Small Molecule Libraries / Muscle Proteins Limits: Humans Language: En Journal: Cell Chem Biol Year: 2019 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Cysteine / Adaptor Proteins, Signal Transducing / DNA-Binding Proteins / Small Molecule Libraries / Muscle Proteins Limits: Humans Language: En Journal: Cell Chem Biol Year: 2019 Type: Article Affiliation country: United States