DNA-Mediated Interferon Signature Induction by SLE Serum Occurs in Monocytes Through Two Pathways: A Mechanism to Inhibit Both Pathways.

Porat, Amit; Giat, Eitan; Kowal, Czeslawa; He, Mingzhu; Son, Myoungsun; Latz, Eicke; Ben-Zvi, Ilan; Al-Abed, Yousef; Diamond, Betty

Porat, Amit; Giat, Eitan; Kowal, Czeslawa; He, Mingzhu; Son, Myoungsun; Latz, Eicke; Ben-Zvi, Ilan; Al-Abed, Yousef; Diamond, Betty.

Affiliation

Porat A; Elmezzi Graduate School for Molecular Medicine, Manhasset, NY, United States.
Giat E; Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, United States.
Kowal C; Elmezzi Graduate School for Molecular Medicine, Manhasset, NY, United States.
He M; Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, United States.
Son M; Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, United States.
Latz E; Center for Molecular Innovation, Feinstein Institute for Medical Research, Manhasset, NY, United States.
Ben-Zvi I; Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, United States.
Al-Abed Y; Biomedical Centre (BMZ), Institute of Innate Immunity, 1G007 University Hospital, University of Bonn, Bonn, Germany.
Diamond B; Center for Autoimmune Musculoskeletal and Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, United States.

Front Immunol ; 9: 2824, 2018.

Article in En | MEDLINE | ID: mdl-30619247

Subject(s)

Antibodies, Antinuclear; Cell-Free Nucleic Acids; Immunoglobulin G; Interferons; Lupus Erythematosus, Systemic; Monocytes; Animals; Antibodies, Antinuclear/blood; Antibodies, Antinuclear/immunology; Cell-Free Nucleic Acids/blood; Cell-Free Nucleic Acids/immunology; Female; HMGB1 Protein/blood; HMGB1 Protein/immunology; Humans; Immunoglobulin G/blood; Immunoglobulin G/immunology; Interferons/blood; Interferons/immunology; Lupus Erythematosus, Systemic/blood; Lupus Erythematosus, Systemic/immunology; Lupus Erythematosus, Systemic/pathology; Male; Mice, Mutant Strains; Monocytes/immunology; Monocytes/metabolism; Monocytes/pathology; Receptors, IgG/immunology; Receptors, IgG/metabolism; omega-Chloroacetophenone

Key words

Fc receptor gamma 2a; monocytes; receptor for advanced glycation end products (RAGE); systemic lupus erythematosus (SLE); type 1 interferon

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Monocytes / Antibodies, Antinuclear / Interferons / Cell-Free Nucleic Acids / Lupus Erythematosus, Systemic Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Front Immunol Year: 2018 Type: Article Affiliation country: United States

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