Unique Transcriptional Architecture in Airway Epithelial Cells and Macrophages Shapes Distinct Responses following Influenza Virus Infection <i>Ex Vivo</i>.

Ma, Joel Z; Ng, Wy Ching; Zappia, Luke; Gearing, Linden J; Olshansky, Moshe; Pham, Kym; Cheong, Karey; Hsu, Arthur; Turner, Stephen J; Wijburg, Odilia; Londrigan, Sarah L; Brooks, Andrew G; Reading, Patrick C

Unique Transcriptional Architecture in Airway Epithelial Cells and Macrophages Shapes Distinct Responses following Influenza Virus Infection Ex Vivo.

Ma, Joel Z; Ng, Wy Ching; Zappia, Luke; Gearing, Linden J; Olshansky, Moshe; Pham, Kym; Cheong, Karey; Hsu, Arthur; Turner, Stephen J; Wijburg, Odilia; Londrigan, Sarah L; Brooks, Andrew G; Reading, Patrick C.

Affiliation

Ma JZ; Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia intuitivelogic.au@gmail.com preading@unimelb.edu.au.
Ng WC; Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia.
Zappia L; Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.
Gearing LJ; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Olshansky M; Department of Molecular and Translational Science, School of Clinical Science, Monash University, Clayton, Victoria, Australia.
Pham K; Department of Microbiology, Monash University, Clayton, Victoria, Australia.
Cheong K; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Hsu A; Department of Molecular and Translational Science, School of Clinical Science, Monash University, Clayton, Victoria, Australia.
Turner SJ; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Wijburg O; Department of Molecular and Translational Science, School of Clinical Science, Monash University, Clayton, Victoria, Australia.
Londrigan SL; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Brooks AG; Department of Molecular and Translational Science, School of Clinical Science, Monash University, Clayton, Victoria, Australia.
Reading PC; Department of Microbiology, Monash University, Clayton, Victoria, Australia.

J Virol ; 93(6)2019 03 15.

Article in En | MEDLINE | ID: mdl-30626665

Subject(s)

Epithelial Cells/virology; Influenza A Virus, H1N1 Subtype/pathogenicity; Lung/virology; Macrophages/virology; Alveolar Epithelial Cells/metabolism; Alveolar Epithelial Cells/virology; Animals; Cell Line; Communicable Diseases/metabolism; Communicable Diseases/virology; Dogs; Epithelial Cells/metabolism; Humans; Influenza, Human/metabolism; Influenza, Human/virology; Interferon Regulatory Factor-3/metabolism; Interferon Regulatory Factor-7/metabolism; Interferons/metabolism; Lung/metabolism; Macrophages/metabolism; Macrophages, Alveolar/metabolism; Macrophages, Alveolar/virology; Madin Darby Canine Kidney Cells; Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections/metabolism; Orthomyxoviridae Infections/virology; Signal Transduction/physiology; Transcription, Genetic/physiology; Virus Replication/physiology

Key words

RNA sequencing; epithelial cell; influenza; lung; macrophage; mouse model

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epithelial Cells / Influenza A Virus, H1N1 Subtype / Lung / Macrophages Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Virol Year: 2019 Type: Article

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