Cotreatment with sorafenib and oleanolic acid induces reactive oxygen species-dependent and mitochondrial-mediated apoptotic cell death in hepatocellular carcinoma cells.

Liese, Juliane; Hinrichs, Tobias M; Lange, Matthias; Fulda, Simone

Liese, Juliane; Hinrichs, Tobias M; Lange, Matthias; Fulda, Simone.

Affiliation

Liese J; Institute for Experimental Cancer Research in Pediatrics.
Hinrichs TM; General and Visceral Surgery, Goethe University.
Lange M; German Cancer Consortium (DKTK), Partner Site Frankfurt, Frankfurt.
Fulda S; Department of General and Thoracic Surgery, Justus-Liebig-University Giessen, Giessen.

Anticancer Drugs ; 30(3): 209-217, 2019 03.

Article in En | MEDLINE | ID: mdl-30640794

Subject(s)

Apoptosis; Carcinoma, Hepatocellular/pathology; Liver Neoplasms/pathology; Mitochondria/drug effects; Oleanolic Acid/pharmacology; Reactive Oxygen Species/metabolism; Sorafenib/pharmacology; Antineoplastic Agents/pharmacology; Carcinoma, Hepatocellular/drug therapy; Carcinoma, Hepatocellular/metabolism; Cell Proliferation; Drug Therapy, Combination; Humans; Liver Neoplasms/drug therapy; Liver Neoplasms/metabolism; Membrane Potential, Mitochondrial/drug effects; Mitochondria/metabolism; Mitochondria/pathology; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oleanolic Acid / Reactive Oxygen Species / Apoptosis / Carcinoma, Hepatocellular / Sorafenib / Liver Neoplasms / Mitochondria Limits: Humans Language: En Journal: Anticancer Drugs Journal subject: ANTINEOPLASICOS Year: 2019 Type: Article

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