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Butenolides from Nectandra oppositifolia (Lauraceae) displayed anti-Trypanosoma cruzi activity via deregulation of mitochondria.
Conserva, Geanne A Alves; da Costa-Silva, Thais A; Amaral, Maiara; Antar, Guilherme M; Neves, Bruno J; Andrade, Carolina H; Tempone, Andre G; Lago, João Henrique G.
Affiliation
  • Conserva GAA; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, 09210-180, São Paulo, Brazil.
  • da Costa-Silva TA; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, 09210-180, São Paulo, Brazil.
  • Amaral M; Centro de Parasitologia e Micologia, Instituto Adolfo Lutz, 01246-902, São Paulo, Brazil.
  • Antar GM; Departamento de Botânica, Instituto de Biociências, Universidade de São Paulo, 05508-090, São Paulo, Brazil.
  • Neves BJ; Laboratorio de Quimioinformática, Centro Universitário de Anápolis - UniEVANGÉLICA, 75070-290, Goiás, Brazil; LabMol, Laboratorio de Modelagem Molecular e Drug Design, Faculdade de Farmácia, Universidade Federal de Goiás, 74605-170, Goiás, Brazil.
  • Andrade CH; LabMol, Laboratorio de Modelagem Molecular e Drug Design, Faculdade de Farmácia, Universidade Federal de Goiás, 74605-170, Goiás, Brazil.
  • Tempone AG; Centro de Parasitologia e Micologia, Instituto Adolfo Lutz, 01246-902, São Paulo, Brazil.
  • Lago JHG; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, 09210-180, São Paulo, Brazil. Electronic address: joao.lago@ufabc.edu.br.
Phytomedicine ; 54: 302-307, 2019 Feb 15.
Article in En | MEDLINE | ID: mdl-30668381
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanocidal Agents / Trypanosoma cruzi / 4-Butyrolactone / Lauraceae / Membrane Potential, Mitochondrial / Mitochondria Limits: Animals / Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Phytomedicine Journal subject: TERAPIAS COMPLEMENTARES Year: 2019 Type: Article Affiliation country: Brazil
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanocidal Agents / Trypanosoma cruzi / 4-Butyrolactone / Lauraceae / Membrane Potential, Mitochondrial / Mitochondria Limits: Animals / Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Phytomedicine Journal subject: TERAPIAS COMPLEMENTARES Year: 2019 Type: Article Affiliation country: Brazil