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EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor.
Elkamhawy, Ahmed; Hassan, Ahmed H E; Paik, Sora; Sup Lee, Yong; Lee, Hwi-Ho; Shin, Ji-Sun; Lee, Kyung-Tae; Roh, Eun Joo.
Affiliation
  • Elkamhawy A; Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. Electronic address: a_elkamhawy@mans.edu.eg.
  • Hassan AHE; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt; Medicinal Chemistry Laboratory, Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address: ahmed_hassan@mans.edu.eg.
  • Paik S; Department of Fundamental Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
  • Sup Lee Y; Medicinal Chemistry Laboratory, Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Fundamental Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Life and Nanopharmaceutical S
  • Lee HH; Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
  • Shin JS; Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
  • Lee KT; Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address: ktlee@khu.ac.kr.
  • Roh EJ; Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea. Electronic address: r8636@kist.re.kr.
Bioorg Chem ; 86: 112-118, 2019 05.
Article in En | MEDLINE | ID: mdl-30685642
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Benzamides / Anti-Inflammatory Agents, Non-Steroidal / Protein Kinase Inhibitors / Amides / Inflammation Limits: Animals / Humans Language: En Journal: Bioorg Chem Year: 2019 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Benzamides / Anti-Inflammatory Agents, Non-Steroidal / Protein Kinase Inhibitors / Amides / Inflammation Limits: Animals / Humans Language: En Journal: Bioorg Chem Year: 2019 Type: Article