Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients.

Aguiar, Renata M; Leão, Raquel A C; Mata, Alejandro; Cantillo, David; Kappe, C Oliver; Miranda, Leandro S M; de Souza, Rodrigo O M A

Aguiar, Renata M; Leão, Raquel A C; Mata, Alejandro; Cantillo, David; Kappe, C Oliver; Miranda, Leandro S M; de Souza, Rodrigo O M A.

Affiliation

Aguiar RM; Biocatalysis and Organic Synthesis Group, ChemistryInstitute, Federal Universityof Rio de Janeiro, 21941-909, Rio de Janeiro, Brazil. rodrigosouza@iq.ufrj.br.

Org Biomol Chem ; 17(6): 1552-1557, 2019 02 06.

Article in En | MEDLINE | ID: mdl-30693360

Subject(s)

Anticonvulsants/chemical synthesis; Anticonvulsants/pharmacology; Antitubercular Agents/chemical synthesis; Antitubercular Agents/pharmacology; Anticonvulsants/chemistry; Antitubercular Agents/chemistry; Chemistry Techniques, Synthetic; Ethambutol/chemical synthesis; Ethambutol/chemistry; Ethambutol/pharmacology; Levetiracetam/chemical synthesis; Levetiracetam/chemistry; Levetiracetam/pharmacology; Pyrrolidinones/chemical synthesis; Pyrrolidinones/chemistry; Pyrrolidinones/pharmacology; Stereoisomerism; Sulfur/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anticonvulsants / Antitubercular Agents Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Type: Article Affiliation country: Brazil

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