Sodium Channels in Human Pain Disorders: Genetics and Pharmacogenomics.

Dib-Hajj, Sulayman D; Waxman, Stephen G

Dib-Hajj, Sulayman D; Waxman, Stephen G.

Affiliation

Dib-Hajj SD; Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA; email: stephen.waxman@yale.edu.
Waxman SG; Rehabilitation Research Center, Veterans Affairs, Connecticut Healthcare System, West Haven, Connecticut 06516, USA.

Annu Rev Neurosci ; 42: 87-106, 2019 07 08.

Article in En | MEDLINE | ID: mdl-30702961

Subject(s)

Sodium Channel Blockers/therapeutic use; Sodium Channels/physiology; Somatoform Disorders/physiopathology; Animals; Carbamazepine/pharmacology; Carbamazepine/therapeutic use; Drug Evaluation, Preclinical; Forecasting; Ganglia, Spinal/physiopathology; Genetic Association Studies; Humans; Nerve Tissue Proteins/chemistry; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/physiology; Peripheral Nerves/physiopathology; Pharmacogenomic Testing; Protein Domains; Sensory Receptor Cells/physiology; Sodium Channel Blockers/pharmacology; Sodium Channels/chemistry; Sodium Channels/genetics; Somatoform Disorders/drug therapy; Somatoform Disorders/genetics; Structure-Activity Relationship

Key words

congenital insensitivity to pain; erythromelalgia; induced pluripotent cells; ion channels; nociceptors; painful peripheral neuropathy; paroxysmal extreme pain disorder; pharmacogenomics; tetrodotoxin-resistant; tetrodotoxin-sensitive

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Somatoform Disorders / Sodium Channels / Sodium Channel Blockers Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Annu Rev Neurosci Year: 2019 Type: Article

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