Lens differentiation is controlled by the balance between PDGF and FGF signaling.

Li, Hongge; Mao, Yingyu; Bouaziz, Michael; Yu, Honglian; Qu, Xiuxia; Wang, Fen; Feng, Gen-Sheng; Shawber, Carrie; Zhang, Xin

Li, Hongge; Mao, Yingyu; Bouaziz, Michael; Yu, Honglian; Qu, Xiuxia; Wang, Fen; Feng, Gen-Sheng; Shawber, Carrie; Zhang, Xin.

Affiliation

Li H; Departments of Ophthalmology, Pathology and Cell Biology, Columbia University, New York, New York, United States of America.
Mao Y; Departments of Ophthalmology, Pathology and Cell Biology, Columbia University, New York, New York, United States of America.
Bouaziz M; Departments of Ophthalmology, Pathology and Cell Biology, Columbia University, New York, New York, United States of America.
Yu H; Departments of Ophthalmology, Pathology and Cell Biology, Columbia University, New York, New York, United States of America.
Qu X; Department of Biochemistry, School of Basic Medicine, Jining Medical University, Jining, Shandong, China.
Wang F; Wuxi School of Medicine, Jiangnan University, Wuxi, Zhejiang China.
Feng GS; Center for Cancer Biology and Nutrition, Texas A&M University, Houston, Texas, United States of America.
Shawber C; Department of Pathology, University of California San Diego, La Jolla, California, United States of America.
Zhang X; Department of Obstetrics and Gynecology, Columbia University, New York, New York, United States of America.

PLoS Biol ; 17(2): e3000133, 2019 02.

Article in En | MEDLINE | ID: mdl-30716082

Subject(s)

Cell Differentiation; Fibroblast Growth Factors/metabolism; Lens, Crystalline/cytology; Lens, Crystalline/metabolism; Platelet-Derived Growth Factor/metabolism; Signal Transduction; Animals; Cell Survival; Epithelial Cells/cytology; Epithelial Cells/metabolism; Lens, Crystalline/embryology; Ligands; MAP Kinase Signaling System; Mice; Mutation/genetics; Phosphatidylinositol 3-Kinases/metabolism; Protein Domains; Protein Stability; Proto-Oncogene Proteins c-akt/metabolism; Receptor, Platelet-Derived Growth Factor alpha/metabolism; Receptors, Notch/chemistry; Receptors, Notch/metabolism; bcl-2 Homologous Antagonist-Killer Protein/genetics; bcl-2-Associated X Protein/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Platelet-Derived Growth Factor / Signal Transduction / Cell Differentiation / Fibroblast Growth Factors / Lens, Crystalline Limits: Animals Language: En Journal: PLoS Biol Journal subject: BIOLOGIA Year: 2019 Type: Article Affiliation country: United States

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