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SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate.
Roy, Michael J; Winkler, Sandra; Hughes, Scott J; Whitworth, Claire; Galant, Michael; Farnaby, William; Rumpel, Klaus; Ciulli, Alessio.
Affiliation
  • Roy MJ; Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee, James Black Centre , Dow Street , Dundee DD1 5EH , United Kingdom.
  • Winkler S; Boehringer Ingelheim RCV GmbH & Co KG , 1221 Vienna , Austria.
  • Hughes SJ; Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee, James Black Centre , Dow Street , Dundee DD1 5EH , United Kingdom.
  • Whitworth C; Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee, James Black Centre , Dow Street , Dundee DD1 5EH , United Kingdom.
  • Galant M; Boehringer Ingelheim RCV GmbH & Co KG , 1221 Vienna , Austria.
  • Farnaby W; Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee, James Black Centre , Dow Street , Dundee DD1 5EH , United Kingdom.
  • Rumpel K; Boehringer Ingelheim RCV GmbH & Co KG , 1221 Vienna , Austria.
  • Ciulli A; Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee, James Black Centre , Dow Street , Dundee DD1 5EH , United Kingdom.
ACS Chem Biol ; 14(3): 361-368, 2019 03 15.
Article in En | MEDLINE | ID: mdl-30721025
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Surface Plasmon Resonance / Proteolysis Type of study: Prognostic_studies Language: En Journal: ACS Chem Biol Year: 2019 Type: Article Affiliation country: United kingdom
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Surface Plasmon Resonance / Proteolysis Type of study: Prognostic_studies Language: En Journal: ACS Chem Biol Year: 2019 Type: Article Affiliation country: United kingdom