Analysis of the role of thrombomodulin in all-trans retinoic acid treatment of coagulation disorders in cancer patients.

Ghaffari, Hamed; Varner, Jeffrey D; Petzold, Linda R

Ghaffari, Hamed; Varner, Jeffrey D; Petzold, Linda R.

Affiliation

Ghaffari H; Department of Mechanical Engineering, University of California Santa Barbara, Santa Barbara, CA, 93106, USA. hamed_ghaffari@umail.ucsb.edu.
Varner JD; School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, 14853, USA.
Petzold LR; Department of Mechanical Engineering, University of California Santa Barbara, Santa Barbara, CA, 93106, USA.

Theor Biol Med Model ; 16(1): 3, 2019 02 14.

Article in En | MEDLINE | ID: mdl-30764845

Subject(s)

Blood Coagulation Disorders/drug therapy; Neoplasms/blood; Neoplasms/drug therapy; Thrombomodulin/metabolism; Tretinoin/therapeutic use; Blood Coagulation/drug effects; Cell Line, Tumor; Computer Simulation; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Gene Expression Regulation, Neoplastic/drug effects; Humans; Models, Biological; Neoplasms/genetics; Thrombin/metabolism; Thrombomodulin/blood; Tretinoin/blood; Tretinoin/pharmacokinetics; Tretinoin/pharmacology

Key words

Acute promyelocytic leukemia; All-trans retinoic acid; Disseminated intravascular coagulation; Mathematical model; Pharmacodynamics; Pharmacokinetics; Thrombomodulin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tretinoin / Blood Coagulation Disorders / Thrombomodulin / Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Theor Biol Med Model Journal subject: BIOLOGIA / MEDICINA Year: 2019 Type: Article Affiliation country: United States

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