Rich fatty acids diet of fish and olive oils modifies membrane properties in striatal rat synaptosomes.
Nutr Neurosci
; 24(1): 1-12, 2021 Jan.
Article
in En
| MEDLINE
| ID: mdl-30822260
ABSTRACT
Background:
Essential fatty acids (EFAs) and non-essential fatty acids (nEFAs) exert experimental and clinical neuroprotection in neurodegenerative diseases. The main EFAs, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), nEFAs, and oleic acid (OA) contained in olive and fish oils are inserted into the cell membranes, but the exact mechanism through which they exert neuroprotection is still unknown. Objectives andMethods:
In this study, we assessed the fatty acids content and membrane fluidity in striatal rat synaptosomes after fatty acid-rich diets (olive- or a fish-oil diet, 15% w/w). Then, we evaluated the effect of enriching striatum synaptosomes with fatty acids on the oxidative damage produced by the prooxidants ferrous sulfate (FeSO4) or quinolinic acid (QUIN). Results andDiscussion:
Lipid profile analysis in striatal synaptosomes showed that EPA content increased in the fish oil group in comparison with control and olive groups. Furthermore, we found that synaptosomes enriched with fatty acids and incubated with QUIN or FeSO4 showed a significant oxidative damage reduction. Results suggest that EFAs, particularly EPA, improve membrane fluidity and confer antioxidant effect.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Synaptosomes
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Cell Membrane
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Oxidative Stress
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Corpus Striatum
/
Fatty Acids
Limits:
Animals
Language:
En
Journal:
Nutr Neurosci
Journal subject:
CIENCIAS DA NUTRICAO
/
NEUROLOGIA
Year:
2021
Type:
Article