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Metabolomic analyses of vigabatrin (VGB)-treated mice: GABA-transaminase inhibition significantly alters amino acid profiles in murine neural and non-neural tissues.
Walters, Dana C; Arning, Erland; Bottiglieri, Teodoro; Jansen, Erwin E W; Salomons, Gajja S; Brown, Madalyn N; Schmidt, Michelle A; Ainslie, Garrett R; Roullet, Jean-Baptiste; Gibson, K Michael.
Affiliation
  • Walters DC; Department of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.
  • Arning E; Baylor Scott & White Research Institute, Institute of Metabolic Disease, Dallas, TX, USA.
  • Bottiglieri T; Baylor Scott & White Research Institute, Institute of Metabolic Disease, Dallas, TX, USA.
  • Jansen EEW; Metabolic Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Center, the Netherlands.
  • Salomons GS; Metabolic Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Center, the Netherlands.
  • Brown MN; Department of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.
  • Schmidt MA; Department of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.
  • Ainslie GR; Department of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.
  • Roullet JB; Department of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.
  • Gibson KM; Department of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA. Electronic address: mike.gibson@wsu.edu.
Neurochem Int ; 125: 151-162, 2019 05.
Article in En | MEDLINE | ID: mdl-30822440
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vigabatrin / Metabolome / Metabolomics / Amino Acids / 4-Aminobutyrate Transaminase Limits: Animals Language: En Journal: Neurochem Int Year: 2019 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vigabatrin / Metabolome / Metabolomics / Amino Acids / 4-Aminobutyrate Transaminase Limits: Animals Language: En Journal: Neurochem Int Year: 2019 Type: Article Affiliation country: United States