Pleomorphic liposarcoma: Updates and current differential diagnosis.
Semin Diagn Pathol
; 36(2): 122-128, 2019 Mar.
Article
in En
| MEDLINE
| ID: mdl-30852046
ABSTRACT
Pleomorphic liposarcoma is the least common but most aggressive subtype of liposarcoma. Tumors most commonly arise in the deep soft tissues of the extremities in adult patients. Pleomorphic liposarcoma has no specific immunohistochemical or molecular genetic features, and the presence of lipoblasts remains the sole diagnostic criterion. Diagnostic challenges include the identification of lipoblasts, which are often scarce or focal, and the distinction from other pleomorphic sarcomas, including dedifferentiated liposarcoma with homologous lipoblastic differentiation. This review provides an updated overview of the clinicopathologic features of pleomorphic liposarcoma, with discussion of its morphologic variants, differential diagnosis, and the role of small biopsy samples.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Soft Tissue Neoplasms
/
Diagnosis, Differential
/
Liposarcoma
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Semin Diagn Pathol
Journal subject:
PATOLOGIA
Year:
2019
Type:
Article
Affiliation country:
United States