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Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.
Harischandra, Dilshan S; Rokad, Dharmin; Neal, Matthew L; Ghaisas, Shivani; Manne, Sireesha; Sarkar, Souvarish; Panicker, Nikhil; Zenitsky, Gary; Jin, Huajun; Lewis, Mechelle; Huang, Xuemei; Anantharam, Vellareddy; Kanthasamy, Arthi; Kanthasamy, Anumantha G.
Affiliation
  • Harischandra DS; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.
  • Rokad D; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.
  • Neal ML; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.
  • Ghaisas S; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.
  • Manne S; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.
  • Sarkar S; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.
  • Panicker N; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.
  • Zenitsky G; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.
  • Jin H; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.
  • Lewis M; Departments of Neurology and Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
  • Huang X; Departments of Neurology and Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
  • Anantharam V; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.
  • Kanthasamy A; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.
  • Kanthasamy AG; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA. akanthas@iastate.edu.
Sci Signal ; 12(572)2019 03 12.
Article in En | MEDLINE | ID: mdl-30862700
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease, Secondary / Corpus Striatum / Alpha-Synuclein / Exosomes / Dopaminergic Neurons / Protein Aggregation, Pathological / Manganese Limits: Animals Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2019 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease, Secondary / Corpus Striatum / Alpha-Synuclein / Exosomes / Dopaminergic Neurons / Protein Aggregation, Pathological / Manganese Limits: Animals Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2019 Type: Article Affiliation country: United States