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EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer.
Wassef, Michel; Luscan, Armelle; Aflaki, Setareh; Zielinski, Dina; Jansen, Pascal W T C; Baymaz, H Irem; Battistella, Aude; Kersouani, Carole; Servant, Nicolas; Wallace, Margaret R; Romero, Pierre; Kosmider, Olivier; Just, Pierre-Alexandre; Hivelin, Mikaël; Jacques, Sébastien; Vincent-Salomon, Anne; Vermeulen, Michiel; Vidaud, Michel; Pasmant, Eric; Margueron, Raphaël.
Affiliation
  • Wassef M; Institut Curie, Paris Sciences et Lettres Research University, 75005 Paris, France.
  • Luscan A; INSERM U934/CNRS UMR3215, 75248 Paris, France.
  • Aflaki S; Institut Curie, Paris Sciences et Lettres Research University, 75005 Paris, France.
  • Zielinski D; INSERM U934/CNRS UMR3215, 75248 Paris, France.
  • Jansen PWTC; Institut Curie, Paris Sciences et Lettres Research University, 75005 Paris, France.
  • Baymaz HI; INSERM U934/CNRS UMR3215, 75248 Paris, France.
  • Battistella A; Institut Curie, Paris Sciences et Lettres Research University, 75005 Paris, France.
  • Kersouani C; INSERM U934/CNRS UMR3215, 75248 Paris, France.
  • Servant N; INSERM U900, Mines ParisTech, 75248 Paris, France.
  • Wallace MR; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, 6525 GA Nijmegen, The Netherlands.
  • Romero P; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, 6525 GA Nijmegen, The Netherlands.
  • Kosmider O; Institut Curie, Paris Sciences et Lettres Research University, 75005 Paris, France.
  • Just PA; INSERM U934/CNRS UMR3215, 75248 Paris, France.
  • Hivelin M; Institut Curie, Paris Sciences et Lettres Research University, 75005 Paris, France.
  • Jacques S; INSERM U934/CNRS UMR3215, 75248 Paris, France.
  • Vincent-Salomon A; Institut Curie, Paris Sciences et Lettres Research University, 75005 Paris, France.
  • Vermeulen M; INSERM U900, Mines ParisTech, 75248 Paris, France.
  • Vidaud M; Department of Molecular Genetics and Microbiology, University of Florida Genetics Institute, University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32610.
  • Pasmant E; Institut Curie, Paris Sciences et Lettres Research University, 75005 Paris, France.
  • Margueron R; INSERM U934/CNRS UMR3215, 75248 Paris, France.
Proc Natl Acad Sci U S A ; 116(13): 6075-6080, 2019 03 26.
Article in En | MEDLINE | ID: mdl-30867289
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polycomb Repressive Complex 2 / Enhancer of Zeste Homolog 2 Protein / Neoplasms Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2019 Type: Article Affiliation country: France
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polycomb Repressive Complex 2 / Enhancer of Zeste Homolog 2 Protein / Neoplasms Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2019 Type: Article Affiliation country: France